Does creatine actually prevent muscle from being broken down?
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Fitness Professional
First a little background on the evidence of how creatine works...
Creatine has been shown to increase the expression of genes that cause muscle fibre growth in both humans and animals. It has also been shown to increase muscle fibre size.
Many (most?) people think that creatine just increases water retention in muscles. This has not been consistently shown in studies and many eminent creatine experts believe that water retention has little or nothing to do with the rapid increases in muscle mass that occur with creatine supplementation.
Any intervention that increases the muscle-building process will prevent muscle breakdown unless the intervention also increases muscle protein breakdown (which creatine does not).
As far as muscle breakdown, studies also show that creatine supplementation results in less loss of muscle when on a calorie-reduced diet.
So yes, there is good evidence that creatine reduces muscle loss and muscle breakdown.
Nutritionist and Supplement Specialist
Supplementation with creatine has been shown to result in greater increases in muscle mass and strength, with a accompanying decrease in myostatin levels. Decreasing myostatin and inhibiting its function by GASP-1, may play an important role in increasing muscle strength and mass with resistance training, but almost certainly leads to a reduced muscle breakdown. So yes, creatine probably does play a role at reducing muscle breakdown.
Health and Fitness Doctor
Nutritionist and Supplement Specialist
Creatine has always played a major role in my diet and has continuously helped me build muscle mass and increase strength. The one thing I personally relied on creatine for was the ability to help me maintain my muscle mass and strength during a dieting phase.
Unfortunately some small amounts of mass reduction are inevitable but the added benefit of creatine play a major role in the prevention of muscle tissue break down.
Fitness Model/Athlete